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When levels drop below the lower quartile of normal range, even if technically 'within normal limits' on a lab report, cardiac rhythm becomes more susceptible to ectopic beats and premature ventricular contractions (PVCs)

Endocrinology (2014) 155(6):226676

The copper concentration used in experiments critically influences cellular responses: low levels (0.10.1.2mmol/l) induce physiological/adaptive transcriptional changes, while higher levels (0.4-0.4.6mmol/l) trigger toxic, stress-related responses [24]

Cao D, Liu Y, Cheng Y, et al

The crop yield component and productivity significantly declined due to Pb toxicity in different rice genotypes [21], where yield reduction was 46.27% to 69.12%