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On the other hand, FOXO4-DRI did not show significant toxicity in normal TM3 Leydig cells (Figure 5B5D), where expression of FOXO4 was low (Figure 3C3E)

Since most reactions in the second stage are spontaneous, tyrosinase acts as the rate-limiting enzyme in melanin synthesis, making it the primary enzyme involved in both enzymatic browning and melanin production 7

Limited research has examined the possible side effects of injecting lipotropic agents

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