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Importantly, Nrf2 can be regulated by p62/SQSTM1 under physiological conditions, i.e., refeeding with a high-carbohydrate diet after fasting, because Ser-351 in the STGE motif can be phosphorylated by mechanistic target of rapamycin complex 1 (mTORC1)

doi: 10.1016/j.nbd.2022.105920 127 DichtlSHaschkaDNairzMSeifertMVolaniCLutzOet al

Oral Glutathione Dietary supplements provide systemic treatment by enhancing GSH levels, increasing absorption, and promoting overall detoxification

doi: 10.1093/neuonc/nox154 42 CloughesyTFDrappatzJde GrootJPradosMDReardonDASchiffDet al

The meal's glycemic index dropped from 86 (high) to 68 (medium), a 21% reduction