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A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma
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TcdA and TcdB are considered the major virulence factors, each consisting of four functional domains: a glucosyltransferase domain (GTD), a cysteine proteinase domain (CPD), a transmembrane domain (TMD), and a C-terminal repetitive oligopeptide domain (CROP) ( Figure 1 ) (Chandrasekaran and Lacy, 2017)
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This even helps doctors tell penile melanosis apart from more serious skin problems, such as melanoma
