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[DOI] [PMC free article] [PubMed] [Google Scholar] 87.Goodman AI, Choudhury M, Da Silva JL, Schwartzman ML, Abraham NG

( a ) The expression of cytosolic or nuclear IDO1 in MCF-7 cells treated with 50 or 100 M H 2 O 2 , or combined with 5 mM NAC was analyzed by Western blot

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Additionally, hyperglycemia has been shown to enhance the repressive histone mark H3K27me3 in human vascular endothelium through upregulation of the methyltransferase EZH2 and suppression of the demethylases UTX/JMJD3, resulting in downregulation of antioxidant genes (e.g., SOD1, SOD2) and elevated NOX4-mediated ROS production [133]

The overarching objective of these bioinformatics-driven discovery endeavors is to elucidate and functionally characterize the metabolites that are encoded by recently identified natural product BGCs (Milshteyn et al., 2018)