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The major sensitivity of mitochondrial DNA to ROS-induced mutagenesis is intuitive, as this DNA is not protected by histones, and mitochondria lack the nucleotide excision repair (NER) enzymatic system
They restore, amplify, or redirect those signals

The radial nerve is the most frequently injured in the upper limb, while the sciatic sustains the most damage in the lower limb 5

Elkins et al., 2006

Zhang, F
