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Taken together, it can be noted that mitochondria play an integral role in both autophagy and apoptosis, the processes implicated in various forms of brain with neurodevelopmental disorder, including ASD

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Lastly, while APOE effects dominated brain profiles, sex effects were more prominent in the periphery, which was also in accordance with a previous study in older (16 months old) APOE-TR mice (Shang et al., 2020), suggesting that regardless of age APOE has a major effect on brain bioenergetics

doi: 10.1007/s11739-020-02470-5