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Reduced glutathione (GSH) provides the active, beneficial form, while oxidized glutathione (GSSG) offers limited therapeutic value

For instance, pharmacological agents that activate mitochondrial biogenesis pathways, such as peroxisome PGC-1, have shown potential in preclinical studies to improve mitochondrial function and protect against both cardiovascular and neurological disorders

In addition, metabolic pathways produce free radicals, that can destroy carbohydrates, lipids, proteins, and nucleic acid

doi: 10.1016/j.placenta.2018.03.003