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A central consequence of this evolution is the failure to establish or sustain a durable AIM, leading to relapse despite the initial response
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Clomipramine is a tertiary amine and undergoes two main steps of metabolism: CYP2C19 : converts clomipramine into desmethylclomipramine , an active metabolite that mainly inhibits noradrenaline reuptake
Trends Cancer 4 , 374384 (2018)
At a loading rate of 50 units per week, one vial lasts about four weeks
