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Since AA147 can be metabolically activated to a reactive electrophile that can covalently modify proteins, we predicted that AA147 activates NRF2 through a mechanism involving metabolic activation and covalent modification of KEAP1
The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach
In conclusion, irisin likely repairs neuronal damage through the SIRT1 pathway
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Targeting metabolic checkpoints such as PKM2 or succinate oxidation can increase the availability of redox-active metabolites that accelerate lipid peroxidation in tumor cells
