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Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

The involvement (or absence of involvement) of the immune system, can serve as a diagnostic hint

The oxaloacetic acid can also be derived from glutamine, thus indicating this pivotal role of glutamine in overall nucleotide homeostasis

& Dekker, C

Targeted delivery of probiotics and their metabolites, based on the pathological link between intestinal microbiota metabolites and ferroptosis, may help inhibit ferroptosis, correct microbiota dysregulation, and restore immune homeostasis, offering a promising precision intervention strategy to alleviate IBD inflammation