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Drugs that usually cannot enter the CNS may become therapeutically beneficial by IN administration, as they bypass the BBB at significantly lower doses, with a subsequent decrease in adverse effects [9]

Ageing is the most significant risk factor of PD, with most cases occurring in patients over 60 years old (Lees et al

All these evidences demonstrated that there are certain connections between amino acid residue modifications, molecular conformation changes, and function changes in albumin, and understanding these is a prerequisite for improved study of the role of albumin PTMs in disease

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