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Chest 122(6 Suppl):289s293s

Three experimental groups were included in the present study: control (CO) group (wild type mice Igf +/+ treated with vehicle for 10 days), Hz (heterozygous group, Igf +/- mice with partial IGF-I deficiency treated with vehicle for 10 days) and Hz + IGF-I group (heterozygous Igf +/- mice treated with 2 g/100 g body weight/day, for 10 days)

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The lack of improvement following antihistamine treatment confirmed the non-histamine-dependent nature of the skin reactions, consistent with other authors observations [6, 8]