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Description
GHS-R1b is a truncated splice variant containing only five transmembrane domains that does not signal in response to ghrelin or GHRPs, but it does heterodimerize with GHS-R1a and attenuate its signaling efficiency in a dominant-negative manner

doi: 10.21873/anticanres.11186 215 ChoiARJee JoMJungMJSik KimHYoonS

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The medication is typically initiated at a lower dose and gradually titrated upward to minimize gastrointestinal side effects and optimize therapeutic benefit

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