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Endocrinology, 150(12), 54785487

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All these variants are associated not only with an increased risk of developing certain types of cancers (i.e., colorectal), but also with a greater susceptibility in developing severe toxicities (grade 3) during different chemotherapy regimens, including those containing taxane

FLG accumulates the keratin filaments within the corneocytes and then facilitates to the formation of a cornified cell envelope adjacent to corneocytes