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Carboxylic acidbased pY mimetics, such as carboxymethylphenylalanine (cmF) and carboxyphenylalanine (cF), have demonstrated promising binding to Grb7-SH2 under physiological conditions (Figure )

10.1038/jp.2012.105 Summary Keywords aminoglycosides, genetic susceptibility, hearing loss, MT-RNR1 mutation, ototoxicity, pediatric, therapeutic drug monitoring Citation Illamola SM, Sherwin CM, Ferguson LC, Birnbaum AK, Elluru RG and Vaughns JD (2026) Mechanisms, prevention, and management of aminoglycoside-induced hearing loss in neonates and children: a translational review

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In the following sections, we will elaborate on the specific impacts of two major therapeutic approachesvaricocele ligation surgery and adjuvant therapy with antioxidants or anti-inflammatory agentson immune-inflammatory interactions, as well as their potential molecular mechanisms and clinical implications

Researchers explored whether magnolol reduces P