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These include neurodegeneration, frailty, osteoporosis, vasomotor dysfunction, hepatic steatosis, insulin resistance, pulmonary fibrosis, chronic kidney disease, and skeletal muscle dysfunction (47)

The efficacy of corticosteroids ranges from approximately 50-84% in RCT clinical studies (Plafki, 2000

The peak concentrations of radioactivity in the kidney, liver, stomach wall, thymus, and spleen were significantly higher than those in the plasma

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Furthermore, the PI3K signaling pathway is putatively altered in the development of AD