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For instance, the progress of atherosclerosis involves an increased number of pro-inflammatory M1 and immunosuppressive M2 macrophages [140] as well as an enhanced accumulation of MDSCs and Tregs [141, 142]

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CrossRef Incidence, mortality and survival of gallbladder, extrahepatic bile duct, and pancreatic cancer using Korea central cancer registry database: 1999-2019 Mee Joo Kang, E Hwa Yun, Kyu-Won Jung, Sang-Jae Park Annals of Hepato-Biliary-Pancreatic Surgery.2022

In the early stage of tumor development, most patients will respond completely or partially to chemotherapy, whereas in the late stage, the therapeutic effect is still unsatisfactory, mainly due to drug resistance (Miller et al., 2019)