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Some studies have found that 0.01% alone as a standalone product did not produce statistically significant photoaging improvements in all trials

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This therapy systematically detoxifies the body, fights the oxidative stress that causes premature aging, and inhibits the production of melanin

doi: 10.1086/315914

Several aspects still need to be clarified: (i) Is this mouse model reliably recapitulating the human scenario of development of autoimmune thyroid diseases, known to have a strong component of genetic predisposition and gender dependence