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Description
It is critical in facilitating the degradation of ubiquitinated -syn through the endosome pathway (Nim et al., 2023)

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In an oxidative ER environment, activated ERO1 generates disulfide bonds by consuming O 2 in the presence of flavin cofactors, which are then passed to the protein for folding via PDI (Bosello-Travain et al., 2013

Nakayama T, Church DF, Pryor WA: Quantitative analysis of the hydrogen peroxide formed in aqueous cigarette tar extracts

The intraneuronal proteinaceous cytoplasmic inclusions now known as LBs, the hallmark of PD, were first described by Lewy in 1912 (Lewy, SNCA ) was identified the following year (Polymeropoulos et al., -Syn Although the full extent of the physiological function for -syn is yet to be revealed and there may be conflicting findings in need of resolution, -syn is involved in synaptic activity through regulation of vesicle docking, fusion, and neurotransmitter release (Ghiglieri et al., There are conflicting findings on the nature of the native state of -syn
