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Regulation of nerve growth factor by anti-inflammatory drugs, a steroid, and a selective cyclooxygenase 2 inhibitor in human intervertebral disc cells stimulated with interleukin-1

But individual peptides also present specific potential risks

Keeton R, Tincho MB, Ngomti A, Baguma R, Benede N, Suzuki A, et al

The peptide is structurally distinct from endogenous growth factors and does not share homology with any known human regulatory peptide outside its parent BPC sequence

The FDA's Category 2 classification makes clinical development in the United States more difficult, not less