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Of note, oxidative protein folding is still possible in hypoxia because ERO1, which transfers electrons to oxygen, can function under low oxygen tension owing to its very low K m for oxygen 30
[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Xiao Z et al
In particular, the PI3K/AKT axis converts phosphatidylinositol-4,5-bisphosphate (PIP 2 ) to phosphatidylinositol 3,4,5-trisphosphate (PIP 3 )
By reducing NF-B activation, quercetin decreases the production of inflammatory mediators, thereby mitigating oxidative damage [209]
