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During GLP-1 treatment , maintain regular contact with your healthcare team and report: Any new or worsening anxiety symptoms , including excessive worry, panic attacks, or physical anxiety symptoms Changes in mood , sleep patterns, or appetite beyond expected treatment effects Difficulty coping with side effects such as nausea, which may exacerbate anxiety Concerns about body image or eating behaviours as weight changes occur NICE guidance recommends holistic care for people with diabetes and obesity, recognising the importance of psychological wellbeing

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PLoS One, 11 (1), Article e0145838

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What has become increasingly clear since 2023 is that GLP-1 receptors are also active in areas of the brain involved in reward, impulse control, motivation, and stress regulation