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Results and Discussion The manuscript discusses the mechanism of action of potential compounds (natural and pharmacologically synthesized), and other advance approaches that could efficiently modulate mitochondrial machinery in terms of regulating mitochondrial biogenesis, mitophagy, bioenergetics pathways, oxidative stress, calcium homeostasis and mitochondrial DNA stability

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This case emphasizes the diagnostic challenge of PTMA in elderly, post-COVID-19 patients, and highlights the importance of distinguishing it from true TMA to avoid unnecessary treatment