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Laboratory assays of oxidative status markers One oxidative damage (protein carbonyls) and two antioxidant (GPX and SOD) blood-based markers were assessed in whole blood samples using commercially available kits commonly applied to mammals 48,49 following the manufacturers instructions unless otherwise mentioned

which occurs in the presence of the GSHS enzyme by amide bond formation between the -carboxyl group of the cysteine moiety in -glutamylcysteine and the -amino group of glycine, to form GSH (Hell and Bergmann 1990

The compound consists of a defined amino acid sequence manufactured using controlled peptide synthesis techniques and processed to research-grade standards

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RNA-seq Differentially expressed genes (DEGs) as can be seen in Table 1, RNA-seq analysis showed that 3107 genes (19.86% of the mPFC-expressed protein-coding genes) in the C- Glud1 +/ /Stress group, 64 in the C- Glud1 +/ /Control group, and 3 in the C-Cre+/Stress group were differentially expressed compared to C-Cre+/Control (FDR-corrected q value 3.31, all p s .239