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63 Together, these findings indicate that (i) the sensitivity of tumors to insulin and IGF-1 parallels their response to CR, and (ii) neither the activation status of PI3KAKT per se nor mutation status of individual genes predicts for the sensitivity of tumors to both growth factors and CR

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To clarify the exact role of IGF-1 in bone, we found by immunohistochemical analysis that a similar number of Osterixpositive osteoprogenitors were on the bone perimeter, indicating migration of MSCs was not affected

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