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Then, once in the extracellular space, GSH is cleaved by -Glutamyl-Transferase (GGT), which is also known as a poor prognostic factor for cancer patients (34)

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In conclusion, OA pathogenesis is propelled by a metabolically dysregulated milieu, where obesity, oxidative stress, gut dysbiosis, and broader metabolic syndrome converge to create a self-perpetuating cycle of inflammation and tissue damage (Figure 1)

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