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It is evidenced by decreased production of perforin and granzyme B, and premature apoptosis [372, 379, 380]

For context, semaglutide typically produces 15-17% weight reduction over similar timeframes, and tirzepatide achieves roughly 20-22%

Mitochondrial DNA repair: a critical player in the response of cells of the CNS to genotoxic insults

Ultra short-loop feedback control of thyrotropin secretion

doi: 10.3389/fmolb.2025.1754469 Received 26 November 2025 Revised 19 December 2025 Accepted 25 December 2025 Published 09 January 2026 Volume 12 - 2025 Edited by Guillermo Moyna, Universidad de la Repblica, Uruguay Reviewed by Khaled Tighanimine, Harvard University, United States Updates Copyright 2026 Chacn, Grnwaldt, Marmisolle, Martnez and Quijano