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RHOAROCK inhibit the myosin phosphatase MYPT1 (also known as PPP1R12A), stimulating the phosphorylation of the myosin regulatory light chain (MLC), tipping the balance towards contractility and enhancing 51 integrin expression on the cell surface

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Pain 155 , 12721279 (2014)

J Neurobiol 62:207218 Pierozan P, Fernandes CG, Dutra MF, Pandolfo P, Ferreira F, de Lima BO, Porciuncula L, Wajner M, Pessoa-Pureur R (2014) Biochemical, histopathological and behavioral alterations caused by intrastriatal administration of quinolic acid to young rats

Then every 6 months once stable