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ENS structure and neurochemistry resemble that of the CNS, the external connections between CNS and ENS include sympathetic and parasympathetic nerve fibers that directly connect from the hindbrain to the gastrointestinal tract

doi: 10.1073/pnas.1606267113

Metformin , the first-line type 2 diabetes drug and an AMPK activator, has cognitive data that are observational and inconsistent, and it lowers BDNF, a growth factor the brain relies on and that exercise raises, which is a reason for caution in a healthy brain

doi: 10.1182/blood.V98.4.1150 52 KhalilBAElemamNMMaghazachiAA

The activation and proliferation of glial cells, in turn, are useful in order to release signaling factors and to trigger a robust immune reaction consisting of brain-resident as well as peripherally recruited inflammatory cells