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1 Introduction Neurodegenerative diseases (NDs) are the prominent source of disability and cause approximately 12% of all deaths at the global level

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References Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Bhatta L

Strengths: Highest documented bioavailability Dose delivery is reliable and predictable Compatible with published dosing protocols Well-documented safety profile Limitations: Requires patient willingness and capability for self-injection Needles, disposal, and injection-site considerations Requires refrigerated storage for most preparations Oral Spray: A Growing Alternative Oral spray formulations deliver peptide into the oral cavity, with absorption occurring through the oral mucosa and variably through ingestion with subsequent partial degradation