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354 Ammonium is mainly produced in the gut by amino acid deamination with subsequent conversion to ammonium by urease containing bacteria and is detoxified in the liver by the urea cycle enzymes and by glutamine synthetase, highly expressed in hepatocytes

For example, SPI-1005 wouldnt be able to cure tinnitus caused by ear blockage, or a vestibular schwannoma (also known as an acoustic neuroma) which would require physical intervention

[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Masson J, et al

47, 48 This cytokine milieu exists in the absence of infection or pathological inflammation, and presumably arises through normal physiological processes within the healthy liver

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