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This interaction induces a proteotoxic stress response that ultimately results in cell death (Tsvetkov et al., 2022)

10.1016/j.jbiosc.2017.03.011 J

435 The continuous development of OVs as combinatorial immunotherapies, particularly with ICIs, CAR-T cells, and BiTEs, holds great promise for overcoming GBMs immunosuppressive barriers and improving patient survival

doi: 10.1097/QAD.0b013e3282f08b97 122 GassenNCNiemeyerDMuthDCormanVMMartinelliSGassenAet al

Cancer Excess ROS in the cell (above its antioxidant capacity) can damage membrane lipids, cause single or double- stranded DNA breaks, modify protein structures and cross-link DNA