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Electron microscopy reveals significant calcium deposits in the ER and mitochondria of necrotic neurons in PD patients, alongside multiple membrane fissures, confirming the pathological role of calcium overload [181]

The participants were then monitored for up to 12 weeks post initial injection, and then an extra 36 months in a follow-up study

In one study of four patients, ultrasound ablation resulted in a gradual, 33% average reduction in Y-BOCS scores over the six months following the procedure, along with rapid and substantial improvements in depression and anxiety (61.1% and 69.4% average reductions, respectively) (Jung 2014)